The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Apr. 09, 2019
Shanghaitech University, Shanghai, CN;
Xiaobao Yang, Shanghai, CN;
Biao Jiang, Shanghai, CN;
Renhong Sun, Shanghai, CN;
Chaowei Ren, Shanghai, CN;
Ning Sun, Shanghai, CN;
Ying Kong, Shanghai, CN;
Yan Li, Shanghai, CN;
Jinju Chen, Shanghai, CN;
Qianqian Yin, Shanghai, CN;
Xiaoling Song, Shanghai, CN;
Quanju Zhao, Shanghai, CN;
Xing Qiu, Shanghai, CN;
ShanghaiTech University, Shanghai, CN;
Abstract
The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.