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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12226405 B1

PDFFull Text
Date of Patent:
Feb. 18, 2025

Filed:

Apr. 27, 2021

Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Robin Alec Fairhurst, Allschwil, CH;

Christine Fritsch, Leymen, FR;

Marc Gerspacher, Hägendorf, CH;

Jürgen Hans-Hermann Hinrichs, Schopfheim, DE;

Jean-Baptiste Georges Armand Langlois, Schlierbach, FR;

Catherine Leblanc, Basel, CH;

Tengfei Li, Shanghai, CN;

Edwige Liliane Jeanne Lorthiois, Niffer, FR;

Christophe Mura, Rosenau, FR;

Cristina Montserrat Nieto-Oberhuber, Binningen, CH;

Milen Todorov, Rosenau, FR;

Andrea Vaupel, Riehen, CH;

Nicolas Warin, Blotzheim, FR;

Rainer Wilcken, Basel, CH;

Assignee:

Novartis AG, Basel, CH;

Attorney:

Derek Denhart

Primary Examiner:

Noble E Jarrell

Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/155 (2006.01); A61K 31/436 (2006.01); A61K 31/4375 (2006.01); A61K 31/4747 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/635 (2006.01); A61K 31/675 (2006.01); A61P 35/00 (2006.01); C07D 471/10 (2006.01); C07D 471/20 (2006.01); C07D 491/20 (2006.01); C07D 491/22 (2006.01); C07D 495/20 (2006.01); C07D 495/22 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 31/155 (2013.01); A61K 31/436 (2013.01); A61K 31/4375 (2013.01); A61K 31/4747 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/635 (2013.01); A61K 31/675 (2013.01); A61P 35/00 (2018.01); C07D 471/10 (2013.01); C07D 471/20 (2013.01); C07D 491/20 (2013.01); C07D 491/22 (2013.01); C07D 495/20 (2013.01); C07D 495/22 (2013.01); C07B 2200/05 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease.

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