The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2025
Filed:
May. 11, 2018
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Beverly L. Davidson, Philadelphia, PA (US);
Yonghong Chen, Philadelphia, PA (US);
Assignee:
The Childeren's Hospital of Philadelphia, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); C12N 7/00 (2006.01); C12N 9/14 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/14 (2013.01); A61K 45/06 (2013.01); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61K 48/0083 (2013.01); A61P 25/00 (2018.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12Y 310/01001 (2013.01);
Abstract
The invention relates to sulfamidase (SGSH) and SGSH variants. SGSH and SGSH variants can be delivered by way of a recombinant adeno-associated virus (rAAV) particle to a mammal's central nervous system (CNS) to transduce CNS cells that contact cerebrospinal fluid (CSF). Target mammals for SGSH and SGSH variant administration include mammals with a deficiency or defect in SGSH expression or function.