The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2025
Filed:
Sep. 05, 2018
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Alok V Joglekar, Pasadena, CA (US);
Michael T Leonard, Pasadena, CA (US);
Michael T Bethune, Pasadena, CA (US);
David Baltimore, Pasadena, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 39/00 (2006.01); A61P 37/00 (2006.01); C07K 14/725 (2006.01); C07K 14/74 (2006.01); C12N 5/0783 (2010.01); C40B 40/02 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 39/4611 (2023.05); A61K 39/4615 (2023.05); A61K 39/4621 (2023.05); A61K 39/4622 (2023.05); A61K 39/4632 (2023.05); A61K 39/46433 (2023.05); A61K 39/464401 (2023.05); A61K 39/464488 (2023.05); A61K 39/464491 (2023.05); A61K 39/464838 (2023.05); A61P 37/00 (2018.01); C07K 14/705 (2013.01); C07K 14/70539 (2013.01); C12N 5/0636 (2013.01); C40B 40/02 (2013.01); G01N 33/566 (2013.01); G01N 33/68 (2013.01); A61K 38/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01); G01N 2333/7051 (2013.01);
Abstract
Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.