The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 11, 2025

Filed:

Mar. 27, 2019
Applicant:

Obi Pharma, Inc., Taipei, TW;

Inventors:

Cheng-Der Tony Yu, Taipei, TW;

Yih-Huang Hsieh, Taipei, TW;

Wei Han Lee, Taipei, TW;

Yu Chen Lin, Taipei, TW;

Nan Hsuan Wang, Taipei, TW;

Assignee:

OBI PHARMA, INC., Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 63/00 (2006.01); A61K 39/39 (2006.01); G01N 30/14 (2006.01); G01N 30/60 (2006.01); G01N 30/74 (2006.01); G01N 30/86 (2006.01); G01N 33/15 (2006.01); A61K 39/00 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
C07J 63/008 (2013.01); A61K 39/39 (2013.01); G01N 30/14 (2013.01); G01N 30/60 (2013.01); G01N 30/74 (2013.01); G01N 30/8631 (2013.01); G01N 30/8675 (2013.01); G01N 33/15 (2013.01); A61K 2039/55577 (2013.01); G01N 2030/027 (2013.01);
Abstract

The present disclosure is related to the six isomer structures (OBI-821-1990-V1A, OBI-821-1990-V1B, OBI-821-1990-V2A, OBI-821-1990-V2B, OBI-821-1858-A, and OBI-821-1858-B) of isolated OBI-821 adjuvant and the method for evaluating the quality thereof. The method of the present disclosure adopts hydrophilic interaction liquid chromatography (HILIC) and reverse phase high performance liquid chromatography (RP-HPLC) either alone or in tandem and is able to separate the isomers of OBI-821 adjuvant in the consequent chromatography. Accordingly, the quality of OBI-821 adjuvant can be further evaluated.


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