The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2025
Filed:
Mar. 18, 2023
Shaanxi Panlong Pharmaceutical Co., Ltd., Shaanxi, CN;
Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd., Shaanxi, CN;
Xiaolin Xie, Xi'an, CN;
Dezhu Zhang, Xi'an, CN;
Zhao Ma, Xi'an, CN;
Boyang Li, Xi'an, CN;
Xuhua Zhou, Xi'an, CN;
Chengyuan Liang, Xi'an, CN;
Liang Xin, Xi'an, CN;
Lei Tian, Xi'an, CN;
Jingyi Li, Xi'an, CN;
Kangxiong Wu, Xi'an, CN;
Shaojun Zhang, Xi'an, CN;
Xiuding Yang, Xi'an, CN;
Sundian Liu, Xi'an, CN;
Yuting Liu, Xi'an, CN;
SHAANXI PANLONG PHARMACEUTICAL CO., LTD., Shaanxi, CN;
XIXIAN NEW DISTRICT FENGHOU ORIGINAL PHARMACEUTICAL TECHNOLOGY CO., LTD., Shaanxi, CN;
Abstract
The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.