The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2025
Filed:
Oct. 24, 2019
Km Biologics Co., Ltd., Kumamoto, JP;
Masaharu Torikai, Kumamoto, JP;
Hiroaki Mori, Kumamoto, JP;
Tomohiro Nishimura, Kumamoto, JP;
Miyuki Matsumoto, Kumamoto, JP;
Hiroyuki Shimizu, Saitama, JP;
Akihiro Koube, Kumamoto, JP;
Takamasa Nagatomo, Kumamoto, JP;
Naoki Inoue, Gifu, JP;
KM Biologics Co., Ltd., Kumamoto, JP;
Abstract
The present invention is directed to provide a modified CMV gB protein that can induce a group of antibodies including a high ratio of neutralizing antibodies that exhibit a high neutralizing activity against a CMV gB protein, in comparison with a wild type CMV gB, upon induction of immunity and that can be used in the prevention and/or treatment of CMV infection and a CMV vaccine comprising the modified CMV gB protein. The modified CMV gB protein according to the present invention is a modified CMV gB protein having an improved ability to induce body region-recognizing antibodies and comprising modification in a head region.