The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2025
Filed:
Oct. 30, 2019
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Sadasivan Vidyasagar, Gainesville, FL (US);
Astrid Grosche, Gainesville, FL (US);
Xiaodong Xu, Gainesville, FL (US);
Shanshan Lin, Gainesville, FL (US);
Sreekala Prabhakaran, Gainesville, FL (US);
AmiLyfe, LLC, Norwood, MA (US);
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Abstract
Provided herein are amino acid compositions useful for increasing the translocation of the cystic fibrosis transmembrane conductance (CFTR) protein from the cytoplasm to the plasma membrane, particularly in epithelial cells. Methods for increasing the concentration of CFTR in the plasma membrane, increasing chloride ion transport, and increasing water transport are also provided. These compositions and methods are useful in treating cystic fibrosis in subjects bearing one or more mutations in the CFTR protein. Use of these compositions for the treatment of cystic fibrosis and in the preparation of a medicament for the treatment of cystic fibrosis are also encompassed herein.