The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2025
Filed:
Feb. 09, 2021
Applicant:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Inventors:
Assignee:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/12 (2015.01); A61K 35/39 (2015.01); A61P 5/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0678 (2013.01); A61K 35/39 (2013.01); A61P 5/50 (2018.01); A61K 2035/126 (2013.01); C12N 2500/46 (2013.01); C12N 2501/11 (2013.01); C12N 2501/117 (2013.01); C12N 2501/119 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/19 (2013.01); C12N 2501/415 (2013.01); C12N 2501/999 (2013.01);
Abstract
Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.