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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12215341 B1

PDFFull Text
Date of Patent:
Feb. 04, 2025

Filed:

Nov. 11, 2019

Hybrid immolative cell-penetrating complexes for nucleic acid delivery

Applicant:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Tim R. Blake, Palo Alto, CA (US);

Robert M. Waymouth, Palo Alto, CA (US);

Paul Wender, Palo Alto, CA (US);

Ronald Levy, Palo Alto, CA (US);

Ole Audun Werner Haabeth, Palo Alto, CA (US);

Matthew Frank, Palo Alto, CA (US);

Adrienne Sallets, Palo Alto, CA (US);

Assignee:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Palo Alto, CA (US);

Attorney:

KDW Firm PLLC

Primary Examiner:

Gregory Listvoyb

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); C08G 63/64 (2006.01); C08G 64/02 (2006.01); C12N 15/88 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/88 (2013.01); A61K 39/001112 (2018.08); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464412 (2023.05); A61K 39/464499 (2023.05); A61K 47/6935 (2017.08); A61P 35/00 (2018.01); A61P 37/04 (2018.01); C08G 63/64 (2013.01); C08G 64/0291 (2013.01); C12N 15/90 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/545 (2013.01); A61K 2039/6025 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05);
Abstract

There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

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