The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 04, 2025

Filed:

Jun. 24, 2022
Applicants:

University of Washington, Seattle, WA (US);

Seattle Children's Hospital, Seattle, WA (US);

Inventors:

Suzie Hwang Pun, Seattle, WA (US);

Meilyn Sylvestre, Seattle, WA (US);

Nataly Kacherovsky, Seattle, WA (US);

Emmeline Cheng, Seattle, WA (US);

Ian Cardle, Seattle, WA (US);

Chris Saxby, Seattle, WA (US);

Assignees:

University of Washington, Seattle, WA (US);

Seattle Children's Hospital, Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); A61K 39/00 (2006.01); C12N 5/0786 (2010.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); A61K 39/4614 (2023.05); A61K 39/4622 (2023.05); A61K 39/4644 (2023.05); C12N 5/0645 (2013.01); C12N 15/1048 (2013.01); C12N 15/1065 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 2310/16 (2013.01);
Abstract

Provided herein are compositions comprising aptamers that specifically bind monocytes and/or macrophage and methods for their use. These aptamer compositions can be used in methods for isolating and/or enriching monocytes and/or macrophages or depleting cell populations of monocytes and/or macrophages. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery.


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