The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2025
Filed:
Nov. 30, 2023
Applicant:
Bayer Aktiengesellschaft, Leverkusen, DE;
Inventors:
Stefan Heitmeier, Wülfrath, DE;
Julia Glunz, Essen, DE;
Melanie Fischer, Riedstadt, DE;
Cindy Schulenburg, Zürich, CH;
Hannah Jörißen, Heiligenhaus, DE;
Christoph Thiel, Cologne, DE;
Andreas Wilmen, Cologne, DE;
Ernst Weber, Langenfeld, DE;
Assignee:
BAYER AKTIENGESELLSCHAFT, Leverkusen, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/38 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 9/10 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 16/38 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 9/10 (2018.01); C12N 15/63 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention i) cross-reacts with rabbit and/or cynomolgus A2AP, ii) does not inhibit human plasmin activity, and iii) increases plasmin mediated clot lysis in the presence of A2AP.