The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 04, 2025

Filed:

Oct. 25, 2023
Applicant:

Amunix Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Volker Schellenberger, Palo Alto, CA (US);

Eric Johansen, Oakland, CA (US);

Angela Henkensiefken, San Jose, CA (US);

Darragh Maccann, Magherfelt, GB;

James McClory, Banbridge, GB;

Philipp Kuhn, Breman, DE;

Andre Frenzel, Braunschweig, DE;

Bryan Irving, Woodside, CA (US);

Mika Derynck, South San Francisco, CA (US);

Assignee:

Amunix Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); C12N 15/70 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/32 (2013.01); C12N 15/70 (2013.01); C07K 2317/31 (2013.01); C07K 2319/30 (2013.01); C12N 2800/101 (2013.01);
Abstract

Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.


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