The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2025
Filed:
Nov. 17, 2021
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Andrew Baik, Scarsdale, NY (US);
Katherine Cygnar, New York, NY (US);
Christopher Schoenherr, Piermont, NY (US);
Christos Kyratsous, Irvington, NY (US);
Cheng Wang, Beijing, CN;
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 38/47 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01); C12N 9/14 (2006.01); C12N 9/24 (2006.01); C12N 9/34 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70596 (2013.01); A61K 38/47 (2013.01); A61P 43/00 (2018.01); C07K 16/2896 (2013.01); C12N 9/14 (2013.01); C12N 9/24 (2013.01); C12N 9/2402 (2013.01); C12N 9/2428 (2013.01); A61K 48/00 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/33 (2013.01); C12N 2710/10043 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Compositions and methods for treating enzyme-deficiency diseases are disclosed. Multidomain therapeutic proteins containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The multidomain therapeutic proteins are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.