The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2025
Filed:
Jul. 24, 2020
Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US);
Angio Dynamics, Inc., Latham, NY (US);
Melvin F. Lorenzo, Blacksburg, VA (US);
Christopher B. Arena, Burlington, NC (US);
Suyashree Bhonsle, Menlo Park, CA (US);
Natalie White, Christiansburg, VA (US);
Lucy Epshteyn, Blacksburg, VA (US);
Rafael V. Davalos, Blacksburg, VA (US);
Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US);
Angio Dynamics, Inc., Latham, NY (US);
Abstract
Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (<<1 s) technique which enables monitoring of inter-burst and intra-burst impedance during EBTs in real-time. FAST identified a frequency which delineates thermal effects from electroporation effects in measured impedance. Significance: FAST demonstrates the potential to perform EIS, in addition to intra-burst impedance spectroscopy, using existing pulse generator topologies.