The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2025
Filed:
Jul. 12, 2022
Toagosei Co., Ltd., Tokyo, JP;
Kyoto University, Kyoto, JP;
Tetsuhiko Yoshida, Ibaraki-ken, JP;
Nahoko Baileykobayashi, Ibaraki-ken, JP;
Kazuo Takayama, Kyoto, JP;
Rina Hashimoto, Kyoto, JP;
Yoshinori Yoshida, Kyoto, JP;
TOAGOSEI CO., LTD., Tokyo, JP;
KYOTO UNIVERSITY, Kyoto, JP;
Abstract
The present disclosure provides siRNA that suppresses proliferation of new coronaviruses (SARS-CoV-2). The siRNA disclosed herein includes: a sense strand; and an antisense strand. The sense strand includes a target sequence comprising 19 to 23 bases in which a base at a 5' terminal is guanine (G) or cytosine (C), and an overhang comprising 2 to 4 bases added to a 3′ terminal side of the target sequence. The antisense strand includes a sequence complementary to the target sequence, and an overhang comprising 2 to 4 bases added to a 3′ terminal side of the complementary sequence. Here, at least a part of the target sequence contains at least a part of a base sequence encoding a signal peptide region of a spike protein (S protein) of SARS-CoV-2.