The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 28, 2025

Filed:

Nov. 18, 2016
Applicant:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

Angela W. Norton, Lexington, MA (US);

Germano Coppola, Lexington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/81 (2006.01); A61K 9/19 (2006.01); A61K 38/00 (2006.01); A61K 38/57 (2006.01); C07K 1/18 (2006.01); C07K 14/76 (2006.01);
U.S. Cl.
CPC ...
C07K 14/8121 (2013.01); A61K 9/19 (2013.01); A61K 38/57 (2013.01); C07K 1/18 (2013.01); C07K 14/76 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/91 (2013.01);
Abstract

The present invention provides, among other things, methods and compositions for treating complement mediated disease. In some embodiments, recombinant human C1 esterase inhibitor proteins having similar or longer half-life than native plasma-derived human C1 esterase inhibitor, and methods of making the same are provided. In some embodiments, the invention provides a method for administering an effective amount of a recombinant human C1 esterase inhibitor protein to an individual who is suffering from or susceptible to a complement-mediated disease such that at least one symptom or feature of said complement-mediated disease is prevented and/or reduced in intensity, severity, or frequency.


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