The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2025
Filed:
Feb. 07, 2023
Applicant:
Virogin Biotech Canada Ltd., Richmond, CA;
Inventors:
Mitchell H. Finer, Cambridge, MA (US);
Lorena Lerner, Cambridge, MA (US);
Christophe Quéva, Cambridge, MA (US);
Edward Kennedy, Cambridge, MA (US);
Assignee:
Virogin Biotech Canada Ltd., Richmond, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/763 (2015.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16643 (2013.01);
Abstract
Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle. Such viral vectors can be used for the treatment and prevention of cancer.