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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12208088 B1

PDFFull Text
Date of Patent:
Jan. 28, 2025

Filed:

Mar. 17, 2021

Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof

Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Sushant Malhotra, Burlingame, CA (US);

Craig Stivala, San Mateo, CA (US);

BinQing Wei, Belmont, CA (US);

Bryan K. Chan, Foster City, CA (US);

Timothy Heffron, Burlingame, CA (US);

Michael Lainchbury, Harlow, GB;

Andrew Madin, Harlow, GB;

Terry Aaron Panchal, Harlow, GB;

Eileen Mary Seward, Harlow, GB;

Toby Blench, Harlow, GB;

Matthew W. Cartwright, Harlow, GB;

Elsa Amandine Dechaux, Harlow, GB;

Richard Elliott, Harlow, GB;

Emanuela Gancia, Harlow, GB;

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:

Craig D Ricci

Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 471/20 (2006.01); C07D 487/04 (2006.01); C07D 487/20 (2006.01); C07D 491/20 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 471/20 (2013.01); C07D 487/04 (2013.01); C07D 487/20 (2013.01); C07D 491/20 (2013.01); C07D 519/00 (2013.01);
Abstract

Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.

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