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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12203098 B1

PDFFull Text
Date of Patent:
Jan. 21, 2025

Filed:

Jun. 30, 2023

Cells having solid tumor targeting backbone and use thereof

Applicant:

Fate Therapeutics, Inc., San Diego, CA (US);

Inventors:

Bahram Valamehr, San Diego, CA (US);

Tom Tong Lee, San Diego, CA (US);

Martin Hosking, San Diego, CA (US);

Eigen Peralta, San Diego, CA (US);

Chia-Wei Chang, San Diego, CA (US);

Assignee:

FATE THERAPEUTICS, INC., San Diego, CA (US);

Attorney:

Greenberg Traurig, LLP

Primary Examiner:

Ilia I Ouspenski

Int. Cl.
CPC ...
C12N 5/078 (2010.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0634 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/3015 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01);
Abstract

Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. Also provided are derivative cells having stable and functional genome editing that delivers improved or enhanced therapeutic effects. Further provided are therapeutic compositions and the use thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.

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