The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
May. 15, 2020
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Ron Weiss, Newton, MA (US);
James J. Collins, Newton, MA (US);
Elvira Vitu, Brookline, MA (US);
Casper Enghuus, Somerville, MA (US);
Jeremy Jonathan Gam, Somerville, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 5/071 (2010.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 5/0677 (2013.01); C12N 15/907 (2013.01); C12N 2310/141 (2013.01); C12N 2310/20 (2017.05); C12N 2506/03 (2013.01); C12N 2800/80 (2013.01); C12N 2830/50 (2013.01);
Abstract
The present disclosure is related to an engineered nucleic acid encoding a post-poly A signal RNA 3' to a terminator for expression of protein, and/or non-coding RNA. Also provided herein are methods for reducing epigenetic silencing, genetic modification, transcriptional regulation of the engineered nucleic acid described herein.