The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 21, 2025

Filed:

Jun. 30, 2022
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Mark Connors, Bethesda, MD (US);

Jinghe Huang, Derwood, MD (US);

Byong Ha Kang, Rockville, MD (US);

John Mascola, Rockville, MD (US);

Elise Ishida, Chevy Chase, MD (US);

Tongqing Zhou, Boyds, MD (US);

Peter Kwong, Washington, DC (US);

Anqi Zheng, Boyds, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61P 31/18 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); A61P 31/18 (2018.01); C07K 16/2809 (2013.01); C07K 16/468 (2013.01); G01N 33/56988 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/76 (2013.01); G01N 2333/162 (2013.01); G01N 2800/26 (2013.01);
Abstract

Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.


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