The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
Jun. 09, 2021
Applicant:
Trustees of Boston University, Boston, MA (US);
Inventors:
John Ngo, Cambridge, MA (US);
Wilson Wong, Brookline, MA (US);
Meng Lai Nicole Wong, Watertown, MA (US);
Huishan Li, Brookline, MA (US);
Elliot P. Tague, Brookline, MA (US);
Assignee:
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/18 (2006.01); C07K 14/81 (2006.01);
U.S. Cl.
CPC ...
C07K 14/1833 (2013.01); C07K 14/811 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/50 (2013.01); C07K 2319/80 (2013.01);
Abstract
The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.