The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
Nov. 10, 2023
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Britta Olenik, Bottrop, DE;
Birgit Keil, Dusseldorf, DE;
Bernd Rösler, Wuppertal, DE;
Peter Fey, Wuppertal, DE;
Heiko Schirmer, Solingen, DE;
Guido Becker, Krefeld, DE;
Julian Egger, Remscheid, DE;
Clemens Bothe, Leverkusen, DE;
Helene Faber, Dormagen, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4'-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.