The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
Aug. 04, 2021
Applicant:
Editas Medicine, Inc., Cambridge, MA (US);
Inventor:
Cecilia Cotta-Ramusino, Cambridge, MA (US);
Assignee:
Editas Medicine, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 19/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01); C12N 15/64 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 48/0083 (2013.01); A61K 48/0091 (2013.01); C07K 19/00 (2013.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/625 (2013.01); C12N 15/64 (2013.01); C07K 2319/20 (2013.01); C07K 2319/80 (2013.01); C07K 2319/85 (2013.01); C12N 2310/20 (2017.05);
Abstract
This application provides improved methods of genome editing. Cas9 molecules can be used to create a break in a genomic region of interest. To increase the likelihood that the break is repaired by HDR (homology-directed repair), the cell can be contacted with molecules that bring a template nucleic acid in close proximity to the break, under conditions that allow the cell to repair the break using the template nucleic acid.