The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
Feb. 27, 2023
Applicant:
Heidelberg Pharma Research Gmbh, Ladenburg, DE;
Inventors:
Christian Lutz, Weinheim, DE;
Jan Anderl, Modautal, DE;
Christoph Mueller, Birkenau, DE;
Werner Simon, Hueffelsheim, DE;
Susanne Werner-Simon, Hueffelsheim, DE;
Torsten Hechler, Lautertal, DE;
Michael Kulke, Ludwigshafen, DE;
Assignee:
Heidelberg Pharma Research GmbH, Ladenburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6831 (2017.08); A61K 47/6851 (2017.08); C07K 16/30 (2013.01);
Abstract
The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6'-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.