The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
Jul. 28, 2016
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
George Cotsarelis, Berwyn, PA (US);
Ying Zheng, West Chester, PA (US);
Jen-Chih Hsieh, South Setauket, NY (US);
David Collins, Philadelphia, PA (US);
Joan O'Brien, Merion Station, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
DP-2 antagonists reversed PGD-mediated human hair growth inhibition in a dose-dependent manner in vitro by reducing PGD-triggered apoptosis and maintaining proliferation of keratinocytes. Hair follicles from approximately half of the alopecia patients exhibited little susceptibility to PGD's effect in vitro. SNPs in the human DP-2 gene were identified that are associated with hair growth inhibition by PGD. These findings underscore the role of DP-2 in regulating hair growth and indicate that DP-2 can be an effective approach in preventing and/or treating androgenetic alopecia in patients sensitive to PGD. Furthermore, the SNPs identified here can be used to identify patients who will benefit from treatment.