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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12196677 B1

PDFFull Text
Date of Patent:
Jan. 14, 2025

Filed:

Oct. 10, 2022

Arrays of integrated analytical devices

Applicant:

Pacific Biosciences of California, Inc., Menlo Park, CA (US);

Inventors:

Annette Grot, Cupertino, CA (US);

Ravi Saxena, Millbrae, CA (US);

Paul Lundquist, San Francisco, CA (US);

Assignee:

PACIFIC BIOSCIENCES OF CALIFORNIA, INC., Menlo Park, CA (US);

Attorney:

VLP Law Group LLP

Primary Examiner:

Sang H Nguyen

Int. Cl.
CPC ...
G01N 21/64 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G02B 6/132 (2006.01); G02B 6/136 (2006.01); G02B 27/42 (2006.01); H01L 27/146 (2006.01); G02B 5/18 (2006.01); G02B 5/20 (2006.01); G02B 5/28 (2006.01); G02B 6/12 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6454 (2013.01); G01N 21/6428 (2013.01); G01N 21/648 (2013.01); G01N 21/7703 (2013.01); G01N 21/78 (2013.01); G02B 6/132 (2013.01); G02B 6/136 (2013.01); G02B 27/4238 (2013.01); G02B 27/4244 (2013.01); H01L 27/14621 (2013.01); H01L 27/14627 (2013.01); H01L 27/14685 (2013.01); G01N 2021/6439 (2013.01); G01N 2021/6478 (2013.01); G01N 2021/7756 (2013.01); G01N 2021/7786 (2013.01); G01N 2201/068 (2013.01); G01N 2201/0873 (2013.01); G02B 5/1895 (2013.01); G02B 5/201 (2013.01); G02B 5/285 (2013.01); G02B 2006/12102 (2013.01); G02B 2006/12109 (2013.01);
Abstract

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

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