The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Jun. 18, 2019
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Pamela B. Conley, Palo Alto, CA (US);
Genmin Lu, Burlingame, CA (US);
Leonard G. Presta, San Francisco, CA (US);
John T. Curnutte, Tustin, CA (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6432 (2013.01); A61K 38/00 (2013.01); C12Y 304/21006 (2013.01);
Abstract
The present disclosure relates to antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. In one embodiment, the derivatives described herein lack or have reduced intrinsic coagulant activity.