The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Jul. 12, 2019
Applicant:
The Trustees of Princeton University, Princeton, NJ (US);
Inventors:
Cliff Brangwynne, Hopewell, NJ (US);
Victoria Drake, Quaker Hill, CT (US);
David Sanders, Princeton, NJ (US);
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY, Princeton, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/14 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); C12Y 306/04012 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/60 (2013.01);
Abstract
A system and method for modulating stress granule assembly, utilizing a protein construct that has a cell penetrating protein fused to one or more proteins that can bind with an NTF2-like domain of a G3BP protein. By configuring the protein construct with an appropriate number of proteins that being with NTF2-like domains, stress granule assembly can be upregulated or downregulated as needed to treat patients.