The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Sep. 11, 2019
Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts, Heidelberg, DE;
Eberhard Karls Universitat Tubingen, Tubingen, DE;
Gundram Jung, Rottenburg, DE;
Helmut Salih, Tubingen, DE;
Fabian Vogt, Neu-Ulm, DE;
Latifa Zekri-Metref, Tubingen, DE;
Martin Pflügler, Tubingen, DE;
Isabelle Ehnes, Tubingen, DE;
Abstract
The present invention provides novel human fins related tyrosine kinase 3 (FLT) antigen binding proteins, such as antibodies, having improved FLTbinding affinity, and/or anti-tumor activity. The FLTantibodies of the invention were generated by mutation of a parent FLTantibody and tested in in vitro in binding assays as well as in vivo in a mouse tumor model and in human patient tumor samples. The antibodies of the invention are provided as monospecific constructs or in a bispecific FLT×CDantibody format and show excellent target affinity and/or tumor cell killing. The present invention also relates methods for producing the antigen binding proteins of the invention as well as nucleic acids encoding them, vectors for and host cells for their expression. The invention further relates to methods of treating or diagnosing a disease such as leukemia using an FLTantigen binding protein (ABP) of the invention.