The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Feb. 01, 2023
Five Prime Therapeutics, Inc., Thousand Oaks, CA (US);
Bristol-myers Squibb Company, Princeton, NJ (US);
Robert J. Johnston, San Mateo, CA (US);
Arvind Rajpal, San Francisco, CA (US);
Paul O. Sheppard, Granite Falls, WA (US);
Luis Borges, Houston, TX (US);
Andrew Rankin, Redwood City, CA (US);
Keith Sadoon Bahjat, Woodside, CA (US);
Alan J. Korman, Piedmont, CA (US);
Andy X. Deng, Princeton, NJ (US);
Lin Hui Su, Somerville, MA (US);
Ginger Rakestraw, Somerville, MA (US);
Five Prime Therapeutics, Inc., Thousand Oaks, CA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.