The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 14, 2025

Filed:

Sep. 12, 2019
Applicants:

Code Biotherapeutics, Inc., Hatfield, PA (US);

Lankenau Institute of Medical Research, Wynnewood, PA (US);

Inventors:

Robert C. Getts, Collegeville, PA (US);

James Kadushin, Gilbertsville, PA (US);

Mindy George-Weinstein, Wynnewood, PA (US);

Jacquelyn Gerhart, Wynnewood, PA (US);

Emanuela Dylgjeri, Hatfield, PA (US);

Kelly Rhodes, Hatfield, PA (US);

Assignees:

CODE BIOTHERAPEUTICS, INC., Hatfield, PA (US);

Lankenau Institute of Medical Research, Wynnewood, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 9/51 (2006.01); A61K 31/704 (2006.01); A61K 31/713 (2006.01); A61K 47/54 (2017.01); A61K 47/62 (2017.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 9/513 (2013.01); A61K 31/704 (2013.01); A61K 31/713 (2013.01); A61K 47/549 (2017.08); A61K 47/62 (2017.08); A61K 47/6849 (2017.08); A61K 47/6859 (2017.08); A61K 47/6925 (2017.08); Y02A 50/30 (2018.01);
Abstract

Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.


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