The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Apr. 28, 2023
Applicant:
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Inventors:
Gemma Zuend, Haywood, CA (US);
Ian Scott, Niwot, CO (US);
Nipun Davar, Pleasanton, CA (US);
Kimiyoshi Annaka, Osaka, JP;
Masahiro Miyake, Osaka, JP;
Motoshi Matsui, Osaka, JP;
Assignee:
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/06 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C07H 19/06 (2013.01); C07H 1/00 (2013.01);
Abstract
The invention relates to methods of synthesizing 2'-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.