The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Apr. 13, 2023
Bayer Aktiengesellschaft, Leverkusen, DE;
Alexandros Vakalopoulos, Hilden, DE;
Marie-Pierre Collin-Kröpelin, Weil am Rhein, DE;
Nuria Ortega Hernandez, Wuppertal, DE;
Andre Dieskau, Wuppertal, DE;
Melissa Boultadakis-Arapinis, Düsseldorf, DE;
Lisa Candish, Wuppertal, DE;
Timo Stellfeld, Berlin, DE;
Ilka Mathar, Düsseldorf, DE;
Lucas Hudson Hofmeister, Berlin, DE;
Peter Sandner, Wuppertal, DE;
Frank Wunder, Wuppertal, DE;
Lisa Dietz, Wuppertal, DE;
Robert Alan Webster, Berlin, DE;
Carsten Schmeck, Mülheim, DE;
Thomas Mondritzki, Essen, DE;
BAYER AKTIENGESELLSCHAFT, Leverkusen, DE;
Abstract
The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).