The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 14, 2025

Filed:

May. 24, 2022
Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Ashok Arasappan, Bridgewater, NJ (US);

Ian M. Bell, Harleysville, PA (US);

Michael J. Breslin, Drexel Hill, PA (US);

Christopher James Bungard, Lansdale, PA (US);

Christopher S. Burgey, Ambler, PA (US);

Harry R. Chobanian, Westfield, NJ (US);

Jason M. Cox, Rancho Santa Fe, CA (US);

Anthony T. Ginnetti, Perkasie, PA (US);

Deodial Guy Guiadeen, Chesterfield, NJ (US);

Kristen L. G. Jones, Oreland, PA (US);

Mark E. Layton, Harleysville, PA (US);

Hong Liu, Hillsborough, NJ (US);

Jian Liu, Norristown, PA (US);

James J. Perkins, Churchville, PA (US);

Shawn J. Stachel, Perkasie, PA (US);

Linda M. Suen-Lai, Philadelphia, PA (US);

Zhe Wu, Blue Bell, PA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 487/04 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.


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