The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Feb. 21, 2019
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Melanie Huttner, Stanford, CA (US);
Paul Wender, Stanford, CA (US);
Lynette Cegelski, Palo Alto, CA (US);
Xiaoyu Zang, Stanford, CA (US);
Alexandra Antonoplis, Stanford, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/64 (2017.01); A61K 38/14 (2006.01); A61K 47/54 (2017.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
A61K 47/645 (2017.08); A61K 38/14 (2013.01); A61K 47/541 (2017.08); A61P 31/04 (2018.01);
Abstract
Antibiotic agents conjugated to a guanidinium-rich molecular transporter (GR-MoTr) are provided. The drug conjugates show surprising increases in efficacy compared to the unconjugated drug in difficult-to-treat bacterial infections including biofilms, stationary and persister cells, and multi-drug resistant bacteria, as well as intracellular bacteria.