The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 14, 2025

Filed:

Mar. 10, 2022
Applicant:

Board of Regents, the University of Texas System, Austin, TX (US);

Inventor:

Jian Yang, State College, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/785 (2006.01); A61K 31/765 (2006.01); A61K 33/42 (2006.01); C08G 63/12 (2006.01); C08G 63/91 (2006.01); C08G 81/00 (2006.01); C08L 67/04 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 31/785 (2013.01); A61K 31/765 (2013.01); A61K 33/42 (2013.01); C08G 63/12 (2013.01); C08G 63/914 (2013.01); C08G 81/00 (2013.01); C08L 67/04 (2013.01); C12N 5/0669 (2013.01); C08L 2203/02 (2013.01); C08L 2205/025 (2013.01); C12N 2500/30 (2013.01); C12N 2500/34 (2013.01); C12N 2501/155 (2013.01); C12N 2533/18 (2013.01);
Abstract

In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.


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