The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
May. 13, 2021
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Assignee:
CITY OF HOPE, Duarte, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); A61K 9/00 (2006.01); A61K 31/7115 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7115 (2013.01); A61K 9/0019 (2013.01); A61P 35/00 (2018.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/317 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/32 (2013.01); C12N 2320/51 (2013.01);
Abstract
Disclosed herein are CCR7 aptamers that specifically bind to and internalize into CCR7-expressing cells. The aptamers can be used as a therapeutic agent by itself or in combination with a small molecule by forming a conjugate with the small molecule. Targeted delivery of the small molecule can be achieved by such conjugates. Also disclosed are methods of treating a subject suffering from cancer by administering an effective amount of the aptamer or the aptamer-small molecule conjugate to the subject.