The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Dec. 27, 2017
Cerner Innovation, Inc., Kansas City, KS (US);
Douglas S. McNair, Leawood, KS (US);
CERNER INNOVATION, INC., Kansas City, MO (US);
Abstract
A system, method and article of manufacture are presented for improving therapy such as adjustment of a chronotherapeutic pharmaceutical regimen. Physiological variables are measured longitudinally and a time series of the measurements is constructed. In some cases, a time series is pre-whitened and transformed to a frequency spectrum while applying multi-taper filtering, and entropy or other statistical measures are calculated for the power spectral distribution. Improved timing, medication and dosage are individually or collectively improved and/or verified through successive testing. An improvement is illustrated for hypertension, using medication to achieve autonomic control and to reduce blood pressure variability and to reduce spectral diversion.