The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Aug. 15, 2022
Applicant:
Iovance Biotherapeutics, Inc., San Carlos, CA (US);
Inventors:
Ian Frank, Tampa, FL (US);
Michael T. Lotze, Pittsburgh, PA (US);
Assignee:
IOVANCE BIOTHERAPEUTICS, INC., San Carlos, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A01N 1/02 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C07K 16/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/85 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A01N 1/0284 (2013.01); A61K 39/4611 (2023.05); A61K 39/46449 (2023.05); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/00 (2013.01); C12N 15/85 (2013.01); G01N 33/5005 (2013.01); A61K 2239/57 (2023.05); C07K 2317/24 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2501/04 (2013.01); C12N 2501/2302 (2013.01); C12N 2502/11 (2013.01); C12N 2502/1121 (2013.01); C12N 2502/99 (2013.01);
Abstract
The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.