The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Nov. 01, 2019
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Frank M. Dyka, Gainesville, FL (US);
William W. Hauswirth, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract
Provided herein are methods and compositions for expressing Otoferlin, e.g., utilizing adeno-associated viral (AAV) particles. Further provided herein are compositions of AAV particles comprising one or more polynucleotides encoding Otoferlin are codon optimized for expression in human cells. Such methods and compositions may be useful for treatment of diseases and disorders such as Deafness, Autosomal Recessive 9 (DFNB9). Also provided are kits comprising such compositions.