The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
May. 18, 2021
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventor:
Frank Rigo, Carlsbad, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 31/7088 (2006.01); A61P 25/28 (2006.01); C12N 5/0793 (2010.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 31/7088 (2013.01); A61P 25/28 (2018.01); C12N 5/0619 (2013.01); C12N 15/113 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0318 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3233 (2013.01); C12N 2510/00 (2013.01);
Abstract
Provided herein are methods for decreasing Ataxin-2 mRNA expression. Such methods are useful to ameliorate symptoms of Ataxin-2 associated diseases. Such Ataxin-2 associated diseases include amyotrophic lateral sclerosis (ALS). Such symptoms include loss of motor function, reduced CMAP amplitude, denervation, and loss of motor neurons.