The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Jun. 08, 2022
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Christine I. Wooddell, Madison, WI (US);
David L. Lewis, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Lauren Almeida, Madison, WI (US);
Steven B. Kanner, Berkeley, CA (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases.