The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Mar. 29, 2019
Nof Corporation, Tokyo, JP;
Tokyo Institute of Technology, Tokyo, JP;
Hiroki Yoshioka, Kawasaki, JP;
Masaki Kamiya, Kawasaki, JP;
Yuji Yamamoto, Kawasaki, JP;
Midori Hirai, Kawasaki, JP;
Akiko Sasaki, Kawasaki, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Makoto Matsui, Tokyo, JP;
Hiroyasu Takemoto, Tokyo, JP;
Kazuki Miyauchi, Tokyo, JP;
Takahiro Nomoto, Tokyo, JP;
Keishiro Tomoda, Tokyo, JP;
NOF Corporation, Tokyo, JP;
Tokyo Institute of Technology, Tokyo, JP;
Abstract
The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L, L, L, Land Lare each independently a single bond or a divalent spacer.