The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Nov. 19, 2021
Applicant:
R.p. Scherer Technologies, Llc, Carson City, NV (US);
Inventors:
Stepan Chuprakov, Emeryville, CA (US);
Ayodele O. Ogunkoya, Berkeley, CA (US);
Assignee:
R.P. Scherer Technologies, LLC, Carson City, NV (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 5/062 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06034 (2013.01); A61K 47/68031 (2023.08); A61K 47/68033 (2023.08); A61K 47/6813 (2017.08); A61K 47/6817 (2017.08); A61K 47/6829 (2017.08); A61K 47/6831 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01);
Abstract
The present disclosure provides antibody-drug conjugate structures, which include a cleavable linker that links the antibody to the drug and has a first enzymatically cleavable moiety and a second enzymatically cleavable moiety which includes a glycoside selected from a galactoside, a glucoside, a mannoside, a fucoside, O-GlcNAc, and O-GalNAc. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.