The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Jan. 17, 2018
Exuma Biotech Corp., West Palm Beach, FL (US);
Bioatla. Inc., San Diego, CA (US);
Gregory Ian Frost, West Palm Beach, FL (US);
James Joseph Onuffer, Jr., Alameda, CA (US);
Jay M. Short, Jackson, WY (US);
Gerhard Frey, San Diego, CA (US);
Hwai Wen Chang, San Marcos, CA (US);
Exuma Biotech Corp., West Palm Beach, FL (US);
BioAtla. Inc., San Diego, CA (US);
Abstract
The present disclosure provides chimeric antigen receptors that bind to Axl and Ror2, and conditionally active chimeric antigen receptors (CARs) that recognize Axl and Ror2. Furthermore, provided herein are nucleic acids encoding these CARs and methods of making and using the CARs, including methods of treating cancer, especially cancers that express Axl and/or Ror2, such as renal cell carcinoma. The present disclosure provides cells genetically modified to produce the CARs.