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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12187681 B1

PDFFull Text
Date of Patent:
Jan. 07, 2025

Filed:

Dec. 14, 2019

Ion channel antagonists/blockers and uses thereof

Applicant:

Shanghai East Hospital, Shanghai, CN;

Inventors:

Yihan Chen, Shanghai, CN;

Dandan Liang, Shanghai, CN;

Yi Liu, Shanghai, CN;

Subas Man Sakya, Shanghai, CN;

Jinhua Yang, Shanghai, CN;

Li Li, Shanghai, CN;

Duanyang Xie, Shanghai, CN;

Dan Shi, Shanghai, CN;

Ke Xiong, Shanghai, CN;

Assignee:

Shanghai East Hospital, Shanghai, CN;

Attorney:

Ice Miller LLP

Primary Examiner:

John S Kenyon

Int. Cl.
CPC ...
C07D 217/24 (2006.01); C07C 39/14 (2006.01); C07C 39/15 (2006.01); C07C 43/20 (2006.01); C07C 43/23 (2006.01); C07C 49/83 (2006.01); C07C 63/38 (2006.01); C07C 211/58 (2006.01); C07C 215/86 (2006.01); C07C 233/65 (2006.01); C07C 235/66 (2006.01); C07C 311/08 (2006.01); C07C 311/24 (2006.01); C07C 311/29 (2006.01); C07C 317/22 (2006.01); C07D 209/34 (2006.01); C07D 211/22 (2006.01); C07D 213/30 (2006.01); C07D 217/02 (2006.01); C07D 231/20 (2006.01); C07D 235/26 (2006.01); C07D 241/42 (2006.01); C07D 295/084 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07D 217/24 (2013.01); C07C 39/14 (2013.01); C07C 39/15 (2013.01); C07C 43/202 (2013.01); C07C 43/23 (2013.01); C07C 49/83 (2013.01); C07C 63/38 (2013.01); C07C 211/58 (2013.01); C07C 215/86 (2013.01); C07C 233/65 (2013.01); C07C 235/66 (2013.01); C07C 311/08 (2013.01); C07C 311/24 (2013.01); C07C 311/29 (2013.01); C07C 317/22 (2013.01); C07D 209/34 (2013.01); C07D 211/22 (2013.01); C07D 213/30 (2013.01); C07D 217/02 (2013.01); C07D 231/20 (2013.01); C07D 235/26 (2013.01); C07D 241/42 (2013.01); C07D 295/084 (2013.01); G01N 33/502 (2013.01);
Abstract

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

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