Reagent manifold with in-line filter

Abstract

Automated biological testing systems may advantageously allow users to perform some maintenance or upkeep of the system, such as replacing or refilling reagent, or replacing gaskets, hoses, filters, and other components. A manifold seal and filtration system including a gasket, retaining ring, and filter is usable with a manifold of such a system to transport reagent from a bottle to the testing system. The gasket includes features to prevent leakage and erroneous installation, and may be replaced by a user during normal maintenance or to select a gasket material to accommodate a particular type of reagent. The retention ring and filter include features to prevent particulate from passing into the testing system when reagent bottles are changed, and to prevent accidental displacement during removal of the gasket, or flushing of the manifold to clean the filter.