The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2025

Filed:

Mar. 06, 2019
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

William R. Bishai, Baltimore, MD (US);

John R. Murphy, Tilghman, MD (US);

Drew M. Pardoll, Brookeville, MD (US);

Laurene Cheung, Baltimore, MD (US);

Juan Fu, Lutherville, MD (US);

Pankaj Kumar, New Delhi, IN;

Amit Kumar, Baltimore, MD (US);

Sadiya Parveen, Baltimore, MD (US);

Cynthia Korin Bullen, Baltimore, MD (US);

Vijayan Sambasivam, Puducherry, IN;

Sumit Siddharth, Baltimore, MD (US);

Dipali Sharma, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 38/20 (2006.01); A61K 38/45 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); A61K 38/2013 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C12Y 204/02036 (2013.01);
Abstract

The present invention is related to a method of treating or preventing cancer in a subject comprising administering to a subject having cancer or prone of getting cancer a first agent that depletes the subject's regulatory T cells (Tregs); followed by administering to the subject a second agent comprising a checkpoint inhibitor.


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